Peripheral inflammation is linked with emotion and mental health in people with obesity. A “head to toe” observational study

Background Obesity is a significant worldwide health problem that linked with mental health. The elucidation of the possible overlapping biochemical mechanism(s) involved in inflammation and oxidative stress imperative to better understand address obesity related metabolic disorders. aim study was investigate associations between inflammatory profiles parameters reflect metabolic, emotional, Greek metabolically unhealthy obese cohort. Methods In total, 122 people were recruited. Anthropometric measurements, biochemical, markers assessed. Quality life evaluated through questionnaires for insomnia, self-esteem, depression, physical Results biomarker tumor necrosis factor-alpha (TNF-α) ratio oxidized low-density lipoprotein/low-density lipoprotein (oxLDL/LDL) higher hypertensive (p=0.002, p=0.001 respectively) hyperglycemic subjects (p=0.017, respectively). Furthermore TNF-α (p<0.001), oxLDL/LDL (p<0.001) oxLDL/high-density (HDL) (p=0.016) increased significantly increase syndrome components. Finally, negative association interleukin-6 (IL-6) Rosenberg Self-Esteem Scale (Beta=-0.019, p=0.019) positive Center Epidemiologic Studies Depression Revised (Beta=0.003, p=0.015) found. Conclusions results suggest obesity-related systemic associated worse self-esteem depression symptoms, indicating an mechanism which can be utilized management obesity.